RT Journal Article
A1 Nur Ahya  Alsabianti
A1 Dian Febrianti Putri  Nampe
A1 Ririn  Arianti
A1 Ihda  Durratunnafisa
A1 Raasikhah Aadilah  Satria
A1 Resky  Wahyuni
A1 Wa Ode Kezya  Azhara
A1 Nurjannah Nurjannah
A1 Agniatul Azizah  Jufri
A1 Andi Utari Prasetya  Ningrum
T1 Dose-dependent muscle relaxant activity of avocado leaf (Persea americana Mill.) extract: Central nervous system effects in mice and implications for phytopharmaceutical development
JF Priviet Social Sciences Journal
YR 2025
VO 5
IS 12
SP 425-433
DO 10.55942/pssj.v5i12.1310
AB Avocado leaves (Persea americana Mill.) contain flavonoids, saponins, and phenols, which are thought to exert muscle-relaxing effects through central nervous system depressant mechanisms. This study investigated the muscle-relaxing effects of avocado leaf extract (Persea americana) in male mice. Nine male mice were divided into three groups and administered 1%, 2%, and 4% avocado leaf infusions orally. Motor activity and reflex responses were observed every 15 min until the 100th min to assess muscle relaxation effects. The results showed that the muscle-relaxation effect increased with increasing extract concentration, at 15.55%, 34.44%, and 42.22%, respectively. Flavonoids and saponins are thought to play a role in increasing GABA activity, which reduces muscle tone. Avocado leaf extract showed muscle relaxation effects that increased with dose and has the potential to be a natural muscle relaxant through GABA activation.
K1 Persea americana, muscle relaxation, flavonoids, GABA, central nervous system
LK https://journal.privietlab.org/index.php/PSSJ/article/view/1310
ER